Mercedes-Benz E 450 Review: Everything You Need to Know
The 2025 Mercedes-Benz E 450 stands as a masterstroke in the brand’s long-standing E-Class lineage. With its blend of muscular performance, luxurious appointments, cutting-edge technology, and refined road manners, the E 450 caters to drivers who expect more than just a premium badge—it satisfies those who demand excellence in every aspect of the driving experience.
Mercedes-Benz built the E 450 not just to impress on paper but to deliver real-world performance with purpose and poise. Let’s explore how this sedan earns its reputation as one of the most complete vehicles in the mid-size luxury segment.
Engine, Performance, and Driving Experience
Under the hood, Mercedes fits the E 450 with a 3.0-liter turbocharged inline-six engine that delivers a potent 375 horsepower between 5,500 and 6,100 rpm. The engine produces 369 lb-ft of torque in the 1,600 to 4,500 rpm range, giving it an aggressive yet refined character.
Mercedes engineers have also equipped this engine with a 48-volt mild-hybrid system, which they call EQ Boost. This system adds short bursts of extra power during acceleration, eliminates turbo lag, and improves efficiency by handling functions like start-stop operations and coasting.
Paired with the smooth-shifting 9G-TRONIC 9-speed automatic transmission, the E 450 accelerates from 0 to 60 mph in just 4.4 seconds. The all-wheel-drive 4MATIC system ensures excellent traction, even during high-speed cornering or adverse weather. Drivers experience a seamless delivery of power and a confident feel behind the wheel, whether cruising down the highway or navigating twisty back roads.
Mercedes has also tuned the suspension system for versatility. It soaks up imperfections when driving through city potholes and transforms into a performance machine on the highway. With adaptive damping and precise steering, the E 450 strikes a balance between luxury and sport.
Fuel Efficiency That Doesn’t Compromise Power
Mercedes designed the E 450 to perform, but it also delivers respectable fuel efficiency. The car offers 22 miles per gallon in the city and 31 miles per gallon on the highway. Thanks to the hybrid assistance and intelligent transmission mapping, the E 450 can glide at low speeds and cruise efficiently on long drives.
These fuel economy numbers make it one of the more efficient options in its performance class, allowing owners to enjoy spirited driving without constantly worrying about fuel stops.
Sophisticated Exterior That Turns Heads
Mercedes styled the E 450 with subtle aggression and undeniable elegance. The 2025 model stands 194.9 inches long, 74 inches wide (excluding mirrors), and 57.9 inches tall. With a 116.6-inch wheelbase, the sedan achieves a balanced look that feels both planted and graceful.
Designers sculpted the hood with fluid lines that guide the eye toward the bold grille, flanked by slim LED headlights. The contoured side panels and chrome-accented window surrounds contribute to a refined profile, while the sloping rear roofline hints at its performance underpinnings. Mercedes completed the rear with wraparound LED taillights and dual chrome exhaust outlets.
Whether parked or in motion, the E 450 radiates confidence and class.
Luxurious Interior With Cutting-Edge Comfort
Step inside the E 450, and Mercedes greets you with a cabin designed to rival first-class airline suites. The company uses only the finest materials—soft-touch leather, open-pore wood, brushed aluminum, and customizable ambient lighting—to create a space that feels timeless and modern.
Occupants benefit from 12-way power-adjustable seats that offer heating, ventilation, and massage functions. Both front and rear passengers enjoy ample legroom and headroom. With 12.7 cubic feet of trunk space, the E 450 accommodates daily errands or weekend getaways with ease.
The cabin feels whisper-quiet, thanks to effective insulation and acoustic glass. Mercedes has meticulously tuned the ride quality to remain composed over rough pavement, potholes, and uneven surfaces. The E 450 never breaks a sweat, even when the road does.
Technology and Infotainment: A Seamless Digital Experience
Mercedes integrates the latest generation of its MBUX (Mercedes-Benz User Experience) infotainment system in the E 450. A dual 12.3-inch display spans the dashboard, serving both as a digital instrument cluster and a touchscreen for media, navigation, and vehicle settings.
The system includes natural voice recognition. Simply say, “Hey Mercedes,” and you can adjust the climate, play music, or get directions without taking your hands off the wheel. Drivers can also use the touchpad on the center console or steering-wheel touch controls to navigate menus.
The E 450 includes:
- Augmented Reality Navigation, which overlays real-time directions onto a video feed of the road ahead
- Burmester surround sound audio, delivering concert-level acoustics
- Wireless charging pads and multiple USB-C ports for device connectivity
- Wireless Apple CarPlay and Android Auto, making smartphone integration seamless
Mercedes backs all this with over-the-air update capabilities, ensuring your car evolves with new features long after you drive it off the lot.
Advanced Safety and Driver Assistance
Safety sits at the core of every Mercedes vehicle, and the E 450 includes a long list of standard and available features to protect both drivers and passengers. Engineers designed the E 450 to anticipate dangers and assist during emergencies.
The car offers:
- Active Brake Assist, which automatically applies brakes to prevent or reduce the severity of collisions
- Blind Spot Assist, which warns drivers of vehicles in their blind zone
- PRE-SAFE® system, which prepares the cabin for impact by tightening seatbelts and closing windows
- Lane Keeping Assist, which gently corrects the vehicle if it starts to drift
- 360-degree camera system, which makes parking and maneuvering stress-free
- Crosswind Assist, which stabilizes the vehicle during strong gusts
Mercedes also includes adaptive cruise control, traffic sign assist, and a driver attention monitor. All of these systems work together to help drivers focus, react quickly, and remain secure.
Ownership Experience and Value
Mercedes-Benz doesn’t just sell a car—it delivers a luxury lifestyle. Owners receive concierge services, access to exclusive driving events, and a premium dealership experience. The brand also provides a 4-year/50,000-mile warranty, along with optional service packages for additional peace of mind.
While the E 450 carries a higher starting price than some rivals, it justifies every penny with its premium build quality, engaging performance, and brand prestige. With fewer compromises and more features than similarly priced sedans, the E 450 ranks among the best investments in its segment.
Final Verdict: A Mid-Size Marvel
The 2025 Mercedes-Benz E 450 raises the bar for luxury sedans. It blends dynamic performance with opulent comfort and innovative technology. Drivers who crave both excitement and refinement will find a perfect partner in the E 450.
From the silky engine to the smart cabin layout, from the futuristic tech to the legacy of German engineering, the E 450 offers something for everyone—whether you enjoy spirited drives, long-distance cruising, or simply making a statement when you pull up to the valet.
Mercedes didn’t just update the E-Class with the E 450. They redefined what a luxury sedan should feel like in the modern world.
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